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Latest publications

Cleary SR, Seflova J, Cho EE, Bisht K, Khandelia H, Espinoza-Fonseca LM, Robia SL: Phospholamban inhibits the cardiac calcium pump by interrupting an allosteric activation pathway. J. Biol. Chem. 300(5):107267, 04/2024. 

Šeflová J, Cruz-Cortés C, Guerrero-Serna G, Robia SL, Espinoza-Fonseca LM*: Mechanisms for cardiac calcium pump activation by its substrate and a synthetic allosteric modulator using fluorescence lifetime imaging. PNAS Nexus.3(1): pgad453, 01/2024. PM38222469

Armanious GP, Lemieux MJ, Espinoza-Fonseca LM, Young HS: Missense variants in phospholamban and cardiac myosin binding protein identified in patients with a family history and clinical diagnosis of dilated cardiomyopathy. Biochim Biophys Acta Mol Cell Res.1871(4): 119699, 04/2024. PM38387507


Rathod N, Guerrero-Serna G, Young HS, Espinoza-Fonseca LM*: Replacement of Lys27 by asparagine in the SERCA regulator myoregulin: A Ca2+ affinity modulator or a catalytic activity switch?. Biochim Biophys Acta Mol Cell Res.1871(1): 119613, 01/2024. PM37918638

Cruz-Cortés C, Velasco-Saavedra MA, Fernández-de Gortari E, Guerrero-Serna G, Aguayo-Ortiz R, Espinoza-Fonseca LM*: A novel machine learning-based screening identifies statins as inhibitors of the calcium pump SERCA. J Biol Chem.299(5): 104681, 05/2023. PM37030504

Liu AY, Rathod N, Guerrero-Serna G, Young HS, Espinoza-Fonseca LM*: Functional Role of an Unusual Transmembrane Acidic Residue in the Calcium Pump Regulator Myoregulin. Biochemistry.62(8): 1331-1336, 04/2023. PM37014032

Bak JJ, Aguayo-Ortiz R, Rathod N, Primeau JO, Khan MB, Robia SL, Lemieux MJ, Espinoza-Fonseca LM, Young HS: Primitive Phospholamban- and Sarcolipin-like Peptides Inhibit the Sarcoplasmic Reticulum Calcium Pump SERCA. Biochemistry.61(14): 1419-1430, 07/2022. PM35771007

Šeflová J, Habibi NR, Yap JQ, Cleary SR, Fang X, Kekenes-Huskey PM, Espinoza-Fonseca LM, Bossuyt JB, Robia SL: Fluorescence lifetime imaging microscopy reveals sodium pump dimers in live cells. J Biol Chem.298(5): 101865, 05/2022. PM35339486


Liu AY, Aguayo-Ortiz R, Guerrero-Serna G, Wang N, Blin MG, Goldstein DR, Espinoza-Fonseca LM*: Homologous cardiac calcium pump regulators phospholamban and sarcolipin adopt distinct oligomeric states in the membrane. Comput Struct Biotechnol J.20: 380-384, 01/2022. PM35035790


Prieto-Martínez FD, Fernández-de Gortari E, Medina-Franco JL, Espinoza-Fonseca LM*: An in silico pipeline for the discovery of multitarget ligands: A case study for epi-polypharmacology based on DNMT1/HDAC2 inhibition. Artificial Intelligence in the Life Sciences.109/2021. PM35475037

Rathod N, Bak JJ, Primeau JO, Fisher ME, Espinoza-Fonseca LM, Lemieux MJ, Young HS: Nothing Regular about the Regulins: Distinct Functional Properties of SERCA Transmembrane Peptide Regulatory Subunits. Int J Mol Sci.22(16)08/2021. PM34445594

Fisher ME, Bovo E, Aguayo-Ortiz R, Cho EE, Pribadi MP, Dalton MP, Rathod N, Lemieux MJ, Espinoza-Fonseca LM, Robia SL, Zima AV, Young HS: Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA. Elife.1006/2021. PM34075877

Aguayo-Ortiz R, Creech J, Jiménez-Vázquez EN, Guerrero-Serna G, Wang N, Monteiro DR A, Herron T, Espinoza-Fonseca LM*: A multiscale approach for bridging the gap between potency, efficacy, and safety of small molecules directed at membrane proteins. Scientific Reports.1108/2021. PM34400719

Espinoza-Fonseca LM*: Structural Basis for the Function of the C-Terminal Proton Release Pathway in the Calcium Pump. Int J Mol Sci.22(7)03/2021. PM33805255

Raguimova ON, Aguayo-Ortiz R, Robia SL, Espinoza-Fonseca LM*: Dynamics-Driven Allostery Underlies Ca2+-Mediated Release of SERCA Inhibition by Phospholamban. Biophys J.119(9): 1917-1926, 11/2020. PM33069270

Aguayo-Ortiz R, Espinoza-Fonseca LM*: Atomistic Structure and Dynamics of the Ca2+-ATPase Bound to Phosphorylated Phospholamban. Int J Mol Sci.21(19)10/2020. PM33019581

Li C, Yue Z, Espinoza-Fonseca LM, Voth GA: Multiscale Simulation Reveals Passive Proton Transport Through SERCA on the Microsecond Timescale. Biophysical Journal.119(5): 1033-1040, 08/2020. PM32814059

Aguayo-Ortiz R, Fernandez-de Gortari E, Espinoza-Fonseca LM*: Conserved C-terminal segment dynamically controls interdomain communication in sarcolipin. Journal of Chemical Information and Modeling.60(8): 3985-3991, 07/2020. PM32668157

Aguayo-Ortiz R, Espinoza-Fonseca LM*: Linking biochemical and structural states of SERCA: achievements, challenges and new opportunities. International Journal of Molecular Sciences.2106/2020. PM32532023

Glaves JP, Primeau JO, Gorski PA, Espinoza-Fonseca LM, Lemieux MJ, Young HS: Interaction of a Sarcolipin Pentamer and Monomer with the Sarcoplasmic Reticulum Calcium Pump, SERCA. Biophys J.118(2): 518-531, 01/2020. PM31858977

Fernández-de Gortari E, Aguayo-Ortiz R, Autry JM, Espinoza-Fonseca LM*: A hallmark of phospholamban functional divergence is located in the N-terminal phosphorylation domain. Comput Struct Biotechnol J.18: 705-713, 01/2020. PM32257054

Espinoza-Fonseca LM*: Probing the effects of nonannular lipid binding on the stability of the calcium pump SERCA. Sci Rep.9(1): 3349, 03/2019. PM30833659

Glaves JP, Primeau JO, Espinoza-Fonseca LM, Lemieux MJ, Young HS: The Phospholamban Pentamer Alters Function of the Sarcoplasmic Reticulum Calcium Pump SERCA. Biophys J.116(4): 633-647, 02/2019. PM30712785

Fernández-de Gortari E, Espinoza-Fonseca LM*: Structural basis for relief of phospholamban-mediated inhibition of the sarcoplasmic reticulum Ca2+-ATPase at saturating Ca2+ conditions. J Biol Chem.293(32): 12405-12414, 08/2018. PM29934304

Fernández-de Gortari E, Espinoza-Fonseca LM*: Preexisting domain motions underlie protonation-dependent structural transitions of the P-type Ca2+-ATPase. Phys Chem Chem Phys.19(15): 10153-10162, 04/2017. PM28374038

Autry JM, Thomas DD, Espinoza-Fonseca LM*: Sarcolipin Promotes Uncoupling of the SERCA Ca2+ Pump by Inducing a Structural Rearrangement in the Energy-Transduction Domain. Biochemistry.55(44): 6083-6086, 11/2016. PM27731980

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