The goal of the Espinoza-Fonseca group is to understand the fundamental molecular motions and interactions that are responsible for regulating calcium transport in muscle cells, and to design effective molecular therapies to treat human diseases associated with dysregulation of calcium transport, such as heart failure and muscular dystrophy. We approach these multidisciplinary problems with a combination of computational methods and experimental techniques.

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Our work has been supported by the National Institutes of Health, Michigan Drug Discovery, the Frankel Cardiovascular Center, and the American Heart Association. We have also been supported by the Advanced Research Computing at the University of Michigan and the Extreme Science and Engineering Discovery Environment (XSEDE).